![]() diabetes mellitus or IV glucose administration), proteinuria, IV contrast, urine contamination, LMW dextran solutions (colloid) ![]() Elevation in specific gravity also occurs with glycosuria (e.g.Dehydration (fever, vomiting, diarrhea), SIADH, adrenal insufficiency, pre-renal renal failure, hyponatraemia with oedema, liver failure, CCF, nephrotic syndrome.Increased specific gravity indicates a concentrated urine with a large volume of dissolved solutes.Chronic Renal Failure (CRF), Chronic glomerulonephritis (GN).In end stage renal disease, specific gravity tends towards 1.010.The glomerular filtrate in Bowman’s space ranges from 1.007 to 1.010, any measurement below this range indicates hydration and any measurement above it indicates relative dehydration.Falsely low specific gravity can be associated with alkaline urine.Specific gravity between 1.002 and 1.035 on a random sample is normal IF kidney function is normal.ĭecreased: 1.022 after a 12 hour period without food or water, renal concentrating ability is impaired and the patient either has generalized renal impairment or nephrogenic diabetes insipidus.Specific Gravity measures the ability of the kidney to concentrate or dilute the urine and is directly proportional to urine osmolality (solute concentration).Specific gravity of urine is a measure of the amount of solutes dissolved in urine as compared to water (1.000). ![]()
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